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KMID : 0043320120350040647
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Archives of Pharmacal Research
2012 Volume.35 No. 4 p.647 ~ p.651
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A new lupane-type triterpene from the seeds of Panax ginseng with its inhibition of NF-κB
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Kim Jeong-Ah
Son Jeong-Hyun
Yang Seo-Young
Song Seok-Bean
Song Gyu-Yong
Kim Young-Ho
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Abstract
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A new lupane-triterpene, 3β-cis-feruloyloxy-16β-hydroxylup-20(29)-ene (1) were isolated from the ethyl acetate extract of Panax ginseng seeds along with the known compound, 3β-transferuloyloxy-16β-hydroxylup-20(29)-ene (2). Compound 2 was isolated from this plant for the first time. Their chemical structures were determined by mass spectroscopy and one-dimensional and two-dimensional magnetic resonance spectra. The bioactive effects of these compounds on TNF-α-induced NF-κB transcription were evaluated in transfected HepG2 cells. Effects on the expression of NF-κB target genes were also examined using a reverse transcription-polymerase chain reaction. Both compounds 1 and 2 were inhibited NF-κB activity in HepG2 cells by decreasing the cellular concentrations of inflammatory factors iNOS and COX2.
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KEYWORD
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Seeds, Panax ginseng, Lupane-type triterpene, NF-κB, COX-2, iNOS
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